Shahriyar Moghanlou and Ehsan Pahlavan gave Persepolis a two-goal cushion going into the break but a Yohan Boli brace kept Qatar's Al Rayyan in contention. Hossein Kanani and Isa Alkasir, however, sealed the points for the Islamic Republic of Iran side.

Persepolis finished top with 15 points while UAE’s Al Wahda, who defeated FC Goa 2-0 in the other match, also advanced to the Round of 16 as one of the best three second-placed finishers.

The two-time finalists had slipped to a 1-0 loss to the club from the United Arab Emirates on Matchday Five, but they eventually claimed all three points against Laurent Blanc’s already-eliminated side after a nervy second half at the Pandit Jawaharlal Nehru Stadium in Goa.

Shahriyar Moghanlou opened the scoring in the 27th minute having earlier hit the crossbar with a header before Ehsan Pahlavan doubled the Iranian side’s advantage seven minutes later. But two goals from Yohan Boli kept Al Rayyan in contention in the second 45 minutes and Persepolis needed further efforts from Hossein Kanani and Isa Alkasir to confirm their fifth victory in six games in the group phase.

With Persepolis FC of the Islamic Republic of Iran having sealed top spot in Group E following an emphatic 4-2 win over Al Rayyan in the earlier match, the best Al Wahda could hope for going into the match against FC Goa was to advance to the Round of 16 as one of the best three second-placed finishers.

They did just that with the win taking Henk ten Cate's side to 13 points which - following the results of other matches on Thursday - assured them of finishing as one of the three best runners-up.

FC Istiklol and Al Hilal are both on 10 points going into Matchday Six but the Tajikistan side will seal top spot should they beat AGMK FC, thanks to a better head-to-head against the 2019 AFC Champions League winners.

Thirteen points, however, may well be enough to take Al Hilal through, with the three best runners-up from the five West groups also advancing to the Round of 16.

A win for Istiklol will mean they will finish as group winners in their debut campaign, irrespective of the Al Hilal FC-Shabab Al Ahli Dubai, with the Tajikistan champions having a better head-to-head record against the 2019 AFc Champions League winners.

Victory will take Esteghlal to 11 points but with Al Duhail of Qatar playing Al Ahli Saudi FC in the group's later match, the Islamic Republic of Iran side will only know their fate hours after their tie against Al Shorta with all three teams tied on eights points going into Matchday Six, setting the stage for an exciting finish to Group C.

Both are tied on eight with Esteghlal FC, with the Islamic Republic of Iran side playing Iraq's Al Shorta earlier on Friday, with only the group winners assured of advancing to the Round of 16.

The three best runners-up from the five AFC Champions League West groups will also advance, meaning Al Duhail and Al Ahli Saudi will have all to play for even if Esteghlal beat Al Shorta.