Shahriar Moghanlou and Mahdi Torabi gave Persepolis a two-goal cushion going into the break before Kamal Kamyabinia and Isa Alkasir completed the win as the 2020 AFC Champions League runners-up made it four wins out of four.

The result means Islamic Republic of Iran's Persepolis will confirm their Round of 16 spot if they avoid defeat against UAE's Al Wahda FSCC on Monday.

Manuchehr Dzhalilov and Manuchehr Safarov scored twice each for the Tajik side, who overwhelmed Rogerio Micale’s side with a barrage of goals either side of half time after Bafetimbi Gomis had opened the scoring on 24 minutes.

The result – one of the shocks of the tournament so far – puts the debutants top of the group with two matches remaining, with Al Hilal’s inferior head-to-head record sending them down to second place despite both clubs having seven points.

The win took Shabab Al Ahli to four points to keep them within sight of Round of 16 qualification with matches against FC Istiklol of Tajikistan and Saudi Arabia’s Al Hilal SFC to come.

Istiklol, who stunned Al Hilal 4-1 on Saturday, lead the group on seven points with the Saudi side second on goal difference. AGMK are on four points.

The result sees the Saudi Pro League side climb to seven points with a game against Esteghlal FC up next, while Al Shorta, whose elimination has been confirmed, take on Qatar’s Al Duhail SC.

Having showed amazing spirit to come from two goals down to defeat the Qatar side 3-2 in their Matchday Three encounter, Al Wahda found it heavy going on Friday against an Al Rayyan team who ended the tie with nine men.

Omar Khrbin, the 2017 AFC Footballer of the Year, broke the deadlock from the penalty spot in the second half but there was late disappointment for Al Wahda as captain Ismael Matar was sent off in added time.

After a goalless first half, Al Nassr sealed the three points thanks to goals from Abdulfattah Asiri and Abderrazak Hamdallah as the Saudi club claimed their second win of the competition.

The win maintained Al Nassr at the top of the standings on eight points, one ahead of Qatar's Al Sadd while Foolad are on five with two Matchdays remaining.

Swiss striker Eren Derdiyok opened the scoring for Uzbekistan's Pakhtakor as his team dominated play, yet Sharjah’s late substitutes Mohammed Khalfan and Abdulaziz Salem combined, the latter assisting the former with just three minutes left on the clock in the Group B tie to salvage a point.