The Qatari side were edged out 2-1 on aggregate in the 2018 semi-final after the teams had also shared a win apiece in the group stage.

Despite their strong domestic form of late – Al Sadd sit top of the Qatar Stars League – the Doha club got off to a poor start on the continent as they lost 2-0 to Saudi Arabia’s Al Ahli last week, and they will be desperate to get points on the board in what is a tough-looking group.

Marat Bikmaev, back at the club for the first time since leaving in 2004, opened the scoring away at Persepolis as Pakhtakor eventually came away from the Islamic Republic of Iran with a credible 1-1 draw on Matchday One.

Pakhtakor, who have Odiljon Xamrobekov available again after suspension, have only twice faced Al Ahli in the competition – back in 2005 when they won 2-1 in Tashkent but lost 3-0 in Jeddah.

Esteghlal and Al Ain had most recently clashed in the 2017 edition in the round of 16. Back then, Kaveh Rezaei gave the Iranian side a 1-0 win in Tehran, but an Omar Abdulrahman masterclass inspired the Emiratis to a 6-1 thumping in the return leg in Al Ain.

Since then, Rezaei and Abdulrahman have both left for pastures new. Esteghlal reached the quarter-finals in 2018, while Al Ain exited at the round of 16 last year.

After a disappointing group stage exit last year, Al Hilal started their 2019 campaign with a bang, earning an important 1-0 win on the road against Al Ain last week to get off the mark.

Tuesday's encounter against Qatar's Al Duhail marks Al Hilal's first-ever continental match at their new home of King Saud University Stadium, which they had moved to in 2018.

With AFC Champions League firsts, a returning star and an intriguing match-up all part of this week’s action, the-AFC.com has picked out five things to look out for on Matchday Two.

The Malaysian champions gave a good account of themselves in their maiden match in the tournament, narrowly going down 2-1 to holders Kashima Antlers in a game that saw recent signing Diogo score his first AFC Champions League goal for the club.

Johor warmed up for the game with a 3-0 victory over PKNP in the Malaysian Super League on Saturday as they remained two points clear at the top of the standings.

Graziano Pelle scored a brace as Shandong played out an entertaining 2-2 draw with Korea Republic’s Gyeongnam FC on Matchday One and they return home for what will be their first ever match against Kashima on the Continent.

The hosts made it successive 2-2 draws at the weekend after a stalemate against Henan Jianye in the Chinese Super League. When Shandong last faced Japanese opposition, meanwhile, they won home and away against Sanfrecce Hiroshima in the 2016 group stage.